PAPA NONOate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PAPA NONOate 是 NO 供体，一氧化氮释放半衰期为 77 分钟 (22-25°C)。PAPA NONOate 可能是一种潜在的研究糖尿病伤口愈合障碍的物质，通过增加伤口部位的胶原合成率。

PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site.

PAPA NONOate (50 μM; 12 h) significantly reduces 70% caspase-3-like activity in caspase-3-overexpressing HUVEC and abolishs the induction of cell death by caspase-3.

PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound.Animal Model:Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound Dosage:100 μM Administration:Wounds received 100 μM PAPA NONOate in phosphate buffer Result:Increased the wound healing rate in test group.

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Proteasome/Ubiquitin

Endogenous Metabolite

Endogenous Metabolite | NO Synthase

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146672-58-4

176.22

C6H16N4O2

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 50 mg/mL (283.74 mM; 超声助溶 (<60°C)

O=NN(O)N(CCC)CCCN

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(-20℃)

With Ice Pack

≥ 2 years