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CQ211
CAS No. 2648986-65-4
CQ211 ( —— )
产品货号. M35729 CAS No. 2648986-65-4
CQ211 是一种有效的、选择性的 RIOK2 抑制剂，Kd 值为 6.1 nM。CQ211 对多种癌细胞均有明显的增殖抑制活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥782 | 有现货 |
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| 10MG | ￥1226 | 有现货 |
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| 25MG | ￥1841 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥899 | 有现货 |
|
生物学信息
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产品名称CQ211
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CQ211 是一种有效的、选择性的 RIOK2 抑制剂，Kd 值为 6.1 nM。CQ211 对多种癌细胞均有明显的增殖抑制活性。
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产品描述CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines.
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体外实验Western Blot Analysis Cell Line:MKN-1 and HT-29 cells Concentration:0, 0.3, 0.6, 1.2, 2.5, and 5.0 μM Incubation Time:4 h Result:Suppresseed the phosphorylation of mTOR in cancer cells.
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体内实验Animal Model:Female CB17-SCID mice (6-8 weeks of age) injected wtih MKN-1 cells Dosage:25 mg/kg Administration:Intraperitoneal administration; for 18 consecutive days; once daily Result:Inhibited the tumor progression with tumor growth inhibition (TGI) of 30.9%.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number2648986-65-4
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分子量521.49
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分子式C26H22F3N7O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 12.5 mg/mL (23.97 mM; 超声助溶 (<60°C)
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SMILESO=C1C2=C(C=3C(N1)=CC=C(C3)C=4C=CC(OC)=NC4)N(N=N2)C5=CC(C(F)(F)F)=C(C=C5)N6CCNCC6
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ouyang Y, et al. Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J Med Chem. 2022 Jun 9;65(11):7833-7842.?
产品手册
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