Anemonin ( —— )

产品货号. M29028 CAS No. 90921-11-2

COA

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HNMR

HPLC

MSDS

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产品名称

Anemonin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

白头翁素是白头翁 (Pulsatilla chinensis Regel) 的天然产物。
产品描述

Anemonin is a natural product from Pulsatilla chinensis Regel.(In Vitro):Human articular chondrocytes and cartilage explants challenged with interleukin-1β (IL-1β) were treated with Anemonin. Anemonin treatment attenuated proteoglycan loss in human cartilage explants treated with IL-1β ex vivo. Anemonin delayed articular cartilage degeneration in vitro. (In Vivo):Destabilization of the medial meniscus (DMM) was performed in 10-week-old male C57BL/6J mice. Anemonin was then intra-articularly injected into the joint capsule for 8 and 12 weeks. Anemonin delayed articular cartilage degeneration in vivo. Anemonin decreased the expressions of matrix metalloproteinase-13 (MMP13), A disintegrin, and metalloproteinase with thrombospondin motifs 5 (ADAMTS5), collagen X (Col X) while increasing Aggrecan level in murine with DMM surgery. Proteoglycan loss and chondrocyte hypertrophy were significantly decreased in Anemonin-treated mice compared with vehicle-treated mice.
体外实验

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体内实验

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靶点

Other Targets
受体

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研究领域

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适应症

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