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Tribendimidine
CAS No. 115103-15-6
Tribendimidine ( —— )
产品货号. M35670 CAS No. 115103-15-6
Tribendimidine 一种广谱的、具有口服活性的驱虫剂，对 A. lumbricoides 和 N. americanus 具有特别高的活性。Tribendimidine 也是 L 型烟碱乙酰胆碱受体 (nAChR) 激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥458 | 有现货 |
|
| 10MG | ￥796 | 有现货 |
|
| 25MG | ￥1558 | 有现货 |
|
| 50MG | ￥2339 | 有现货 |
|
| 100MG | ￥3398 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥675 | 有现货 |
|
生物学信息
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产品名称Tribendimidine
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Tribendimidine 一种广谱的、具有口服活性的驱虫剂，对 A. lumbricoides 和 N. americanus 具有特别高的活性。Tribendimidine 也是 L 型烟碱乙酰胆碱受体 (nAChR) 激动剂。
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产品描述Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist.
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体外实验Tribendimidine (100 μg/mL; 24 h) shows intoxication of C. elegans.Tribendimidine (0-100 μg/mL; 6 days) shows toxicity with an LC50 value (concentration at which half the animals are dead) of 54.4 μg/mL.Tribendimidine (0-200 μg/mL; 64 h)-induced sterility is resisted by trb mutant hermaphrodites, and Levamisole-resistant mutants are resistant to Tribendimidine.
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体内实验Tribendimidine (75 and 150 mg/kg; p.o.; once) shows inhibition activity against C. sinensis in rats, and shows inhibition against O. viverrini at 400 mg/kg in hamsters.Animal Model:C. sinensis infected Female Wistar rats Dosage:75 mg/kg and 150 mg/kg Administration:Oral administration, once Result:A 99.1% worm burden reduction was achieved at 150 mg/kg, and the worm burden reduction was still significant (68.9%) at 75 mg/kg.
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同义词——
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通路Cell Cycle/DNA Damage
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靶点AChR
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受体AChR
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研究领域——
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适应症——
化学信息
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CAS Number115103-15-6
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分子量452.59
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分子式C28H32N6
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 50 mg/mL (110.48 mM; 超声助溶 酸性条件溶解 (HCL 调节，pH≈3)
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SMILESCN(C)C(\C)=N\c1ccc(cc1)\N=C\c1ccc(\C=N\c2ccc(cc2)\N=C(/C)N(C)C)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Xiao SH, et al. Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop. 2005 Apr;94(1):1-14.?
产品手册
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