NS9283

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NS9283 是一种选择性 α4β2 形式的正变构调节剂，可减少乙醇消耗。

NS9283, a positive allosteric modulator selective for the α4β2 form, reduces ethanol consumption.(In Vitro):NS9283 increased the potency of varenicline to activate and desensitize α4β2?nAChRs in vitro without affecting other known targets of varenicline.(In Vivo):In male and female C57BL/6J mice, NS9283 (10 mg/kg) reduced ethanol intake in a two-bottle choice, intermittent drinking procedure without affecting saccharin intake, ethanol-induced incoordination or ethanol-induced loss of the righting reflex. Subthreshold doses of NS9283 (2.5 mg/kg) plus varenicline (0.1 mg/kg) synergistically reduced ethanol intake in both sexes. Finally, despite having no aversive valence of its own, NS9283 enhanced ethanol-conditioned place aversion.

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NS 9283 | NS-9283

Cell Cycle/DNA Damage

AChR

lignostilbene-α,β-dioxygenase

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913830-15-6

248.245

C14H8N4O

>98% (HPLC)

In Vitro:?DMSO : 16.67 mg/mL (67.15 mM)

N#Cc1cccc(c1)-c1nc(no1)-c1cccnc1

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(-20℃)

With Ice Pack

≥ 2 years