AGN 192870

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AGN 192870 是一种 RAR 中性拮抗剂，对 RARα、RARβ 和 RARγ 的Kd 分别为 147、33 和 42 nM。AGN 192870 对于 RARα 和 RARγ 的 IC50 分别为 87 和 32 nM。AGN 192870 显示 RARβ 部分激动作用。

AGN 192870 is a RAR neutral antagonist with Kds of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. AGN 192870 shows IC50s of 87 and 32 nM for RARαand RARγ, respectively. AGN 192870 shows RARβ partial agonism. AGN 192870 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Apoptosis

Apoptosis

Apoptosis | Retinoid Receptor

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166977-57-7

378.46

C27H22O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 6.25 mg/mL (16.51 mM; 超声助溶 (<60°C)

CC1(C)C=2C(C(=CC1)C3=CC=CC=C3)=CC(C#CC4=CC=C(C(O)=O)C=C4)=CC2

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(-20℃)

With Ice Pack

≥ 2 years