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IndiMitecan
CAS No. 915360-05-3
IndiMitecan ( —— )
产品货号. M35375 CAS No. 915360-05-3
Indimitecan (LMP776) 是一种拓扑异构酶 I (Top1) 抑制剂，具有抗癌活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2043 | 有现货 |
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| 10MG | ￥3126 | 有现货 |
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| 25MG | ￥5013 | 有现货 |
|
| 50MG | ￥7022 | 有现货 |
|
| 100MG | ￥8883 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称IndiMitecan
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Indimitecan (LMP776) 是一种拓扑异构酶 I (Top1) 抑制剂，具有抗癌活性。
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产品描述Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities.
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体外实验Indimitecan (LMP776) (0-100 μM) shows antiproliferative potencies against various human cancer cell lines, with mean-graph midpoint (MGM) of 0.079 ± 0.023 μM.Indimitecan shows potent DNA cleavage due to Top1 inhibition.Indimitecan can be substrates for metabolic ketone reductases.Cell Proliferation Assay Cell Line:HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145, MCF-7Concentration:0-100 μM Incubation Time: Result:Showed growth inhibition with GI50s of <0.01, <0.01, 0.04, <0.01, 0.08, <0.01, <0.01 and 0.01 μM against HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145 and MCF-7 cells, respectively. And the mean-graph midpoint (MGM) for growth inhibition of all human cancer cell lines successfully tested (the National Cancer Institute’s developmental therapeutics assay (the “NCI60”)) was 0.079 ± 0.023 μM.
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体内实验——
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同义词——
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通路Cell Cycle/DNA Damage
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靶点Topoisomerase
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受体Topoisomerase
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研究领域——
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适应症——
化学信息
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CAS Number915360-05-3
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分子量459.45
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分子式C25H21N3O6
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 8.33 mg/mL (18.13 mM; 超声助溶 (<60 ℃)；酸性条件溶解 (HCL 调节，pH=3)
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SMILESCOc1cc2c3C(=O)c4cc5OCOc5cc4-c3n(CCCn3ccnc3)c(=O)c2cc1OC
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Cinelli MA, et al. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as to?
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