LMPTP INHIBITOR 1 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LMPTP inhibitor 1 hydrochloride 是一种选择性的低分子量蛋白酪氨酸磷酸酶 (LMPTP) 抑制剂，能够抑制 LMPTP-A 的活性，IC50 值为 0.8 μM。

LMPTP inhibitor 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.

LMPTP inhibitor 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50 of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) hydrochloride also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes.

LMPTP inhibitor 1 hydrochlorideis orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 (0.05% w/w) hydrochloride inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight.

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Metabolic Enzyme/Protease

Phosphatase

Phosphatase

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2310135-38-5

481.07

C28H37ClN4O

>98% (HPLC)

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CCN(C(c1ccc(c(cc2NCCCN3CCCCC3)nc4c2cccc4)cc1)=O)CC.Cl

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(-20℃)

With Ice Pack

≥ 2 years