NSC-87877

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NSC-87877 是 Shp2 和 Shp1 蛋白酪氨酸磷酸酶的有效抑制剂（IC50=0.318 μM，shp2 和 shp1 分别为 0.355 μM）。它还抑制双特异性磷酸酶 26 (DUSP26)。

NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phosphatase 26 (DUSP26).

Cell Viability Assay Cell Line:p53 wild-type neuroblastoma (NB) cell lines.Concentration:0, 0.25, 0.5 μM.Incubation Time:5 dsys.Result:Resulted in increased p53 phosphorylation (Ser37 and Ser46) and activation, increased activation of downstream p38 effector proteins (heat shock protein 27 (HSP27) and MAP kinase-activated protein kinase 2 (MAPKAPK2)) and poly ADP ribose polymerase/caspase-3 cleavage.Inhibited DUSP26 function in NB cell lines.Resulted in apoptosis in many cell lines at varying IC50 levels of 1.84 μM (IMR32), 6.35 μM (SK-N-SH), 8.69 μM (NB-19), 12.6 μM (SMS-KCN), 15.7 μM (SH-SY5Y), 15.8 μM (JF) and 19.0 μM (CHLA-225), respectively.

Animal Model:Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice.Dosage:30?mg/kg.Administration:IP once daily for 15 days.Result:Significantly inhibited NB tumor growth.

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Metabolic Enzyme/Protease

Phosphatase

SHP-2|SHP-1|DUSP26

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56990-57-9

459.45

C19H13N3O7S2

>98% (HPLC)

DMSO:4 mg/mL(8.71 mM)

Oc1c(cc(c2cccnc12)S(O)(=O)=O)\N=N\c1ccc2cc(ccc2c1)S(O)(=O)=O

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(-20℃)

With Ice Pack

≥ 2 years