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Renzapride
CAS No. 112727-80-7
Renzapride ( —— )
产品货号. M35046 CAS No. 112727-80-7
Renzapride (BRL 24924)，是一种取代苯甲酰胺，是 5-HT4 受体激动剂，也是 5HT2b 和 5HT3 受体拮抗剂。Renzapride (BRL 24924) 可以用于便秘型肠易激综合征 (C-IBS) 的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3544 | 有现货 |
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| 10MG | ￥5054 | 有现货 |
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| 25MG | ￥7301 | 有现货 |
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| 50MG | ￥10044 | 有现货 |
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| 100MG | ￥13050 | 有现货 |
|
| 200MG | ￥17640 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Renzapride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Renzapride (BRL 24924)，是一种取代苯甲酰胺，是 5-HT4 受体激动剂，也是 5HT2b 和 5HT3 受体拮抗剂。Renzapride (BRL 24924) 可以用于便秘型肠易激综合征 (C-IBS) 的研究。
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产品描述Renzapride (BRL 24924), a substituted benzamide, is a full 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride (BRL 24924) is also a 5HT2b and 5HT3 receptor antagonist. Renzapride could be used for constipation predominant irritable bowel syndrome (C-IBS) study.
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体外实验Renzapride replaces specific binding of [H3] GR 113808 (a selective 5-HT receptor antagonist) to cloned human 5-HT4 receptors with a Ki value of 115 nM.
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体内实验Renzapride (BRL 24924) (100 μg i.v.) results in a partial reverse of both the delayed solid and liquid meals emptying.Renzapride (BRL 24924) (0.5-1 mg/kg) significantly increases the rate of emptying of a 51Cr-labeled liquid meal from the murine stomach.Animal Model:Dog (simulating gastroparesis)Dosage:100 μg/kg Administration:i.v.Result:Results in a partial reverse of both the delayed solid and liquid meals emptying.Animal Model: Mice (30-45g) Dosage:0.5-1 mg/kg Administration:p.o.Result:Significantly increase the rate of emptying of a 51Cr-labeled liquid meal from the murine stomach.
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同义词——
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通路GPCR/G Protein
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靶点5-HT Receptor
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受体5-HT Receptor
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研究领域——
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适应症——
化学信息
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CAS Number112727-80-7
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分子量323.82
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分子式C16H22ClN3O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 25 mg/mL (77.20 mM; 超声助溶 )
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SMILESCOc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN2CCC[C@@H]1C2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Camilleri M, et al. Effect of renzapride on transit in constipation-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol. 2004;2(10):895-904.?
产品手册
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