SR-57227 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SR-57227 是一种高亲和力、选择性 5-HT3 受体激动剂，在体内具有抗惊厥作用。

SR-57227 is a high affinity, selective 5-HT3 receptor agonist, demonstrates anticonvulsant effects in vivo.Depression Discontinued.

SR 57227A binds to 5-HT3 receptors labelled with [3H]S-zacopride with an affinity (Ki) of 115 nM in rat cerebral cortex, 150 nM in NG 108-15 cell membranes and 103 nM in whole NG 108-15 cell.

SR 57227A (1-30 mg/kg; i.p.) dose-dependently reduces immobility time in the forced swimming test with an ED50 value for this effect of 14.2 mg/kg.In the forced swimming test, SR 57227A dose-dependently reduces the duration of immobility in rats after i.p. administration. (ED50=7.6 mg/kg i.p. in rats.) SR 57227A is also active in both species after oral administration. In a time-course study in mice, SR 57227A (20 mg/kg p.o.) produces a significant effect lasting 6 hours. SR 57227A (1 and 3 mg/kg i.p.) reduces the elevation of the escape failures in the learned helplessness model in rats by 50-60% on the last two days of the avoidance task, and reduces isolation-induced aggressivity in mice by 50 to 85%, an effect which is antagonised by Zacopride (1 mg/kg i.p.).

SR 57227 | SR57227

GPCR/G Protein

5-HT Receptor

5-HT Receptor

Neurological Disease

Depression

77145-61-0

248.151

C10H15Cl2N3

>98% (HPLC)

In Vitro:?H2O : 33.33 mg/mL (134.31 mM)

C1CN(CCC1N)C2=NC(=CC=C2)Cl.Cl

1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride

(-20℃)

With Ice Pack

≥ 2 years