MnTBAP chloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MnTBAP chloride 是一种超氧化物歧化酶 (SOD) 模拟物和过氧亚硝酸盐清除剂。MnTBAP chloride 是一种锰卟啉配合物，具有抗氧化性能。MnTBAP chloride 通过上调 BMPR-II 和抑制 NFκB 信号传导介导抗炎作用。MnTBAP chloride 具有抗氧化性能，具有用于研究慢性肾脏疾病 (CKDs) 纤维化反应的潜力。

MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research.

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Animal Model:C57BL/6J mice with 5/6 nephrectomy (Nx)Dosage:10?mg/kg Administration:IP; three times per week for twelve weeks Result:Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.

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Others

Antioxidant

Antioxidant | NF-κB

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55266-18-7

876.13

C48H25ClMnN4O8

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (113.75 mM; 超声助溶 ) 0.5 M NaOH 中的溶解度 : 20 mg/mL (22.75 mM; 超声助溶) 1M NaOH 中的溶解度 : 10 mg/mL (11.37 mM; ultrasonic and adjust pH to 8 with NaOH)

[H+].O=C([O-])C=1C=CC(=CC1)C2=C3C=CC=4C(C=5C=CC(=CC5)C(=O)[O-])=C6C=CC7=C(C8=CC=C(C=C8)C(=O)[O-])C=9C=CC%10=C(C%11=CC=C(C=C%11)C(=O)[O-])C%12=CC=C2[N-]%12[Mn+3]([Cl-])([N]34)([N]%109)[N-]67

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(-20℃)

With Ice Pack

≥ 2 years