Sinigrin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

黑芥子苷是一种芥子油苷，可用作识别、区分和表征黑芥子酶/硫代葡萄糖苷葡萄糖水解酶/硫代葡萄糖苷酶的系统化合物。

Sinigrin, a glucosinolate, is used as a systrate to identify, differentiate and characterize myrosinase(s)/thioglucoside glucohydrolase(s)/thioglucosidase(s). Sinigrin is used as a reference material in procedures for the isolation and identification of glucosinolates.

Cell Cycle Analysis Cell Line:3T3-L1 adipocytes Concentration:100 μg/mL Incubation Time:24 h Result:Arrested cells in the G0/G1phase of the cell cycle and increased the expression of p21 and p27.Western Blot Analysis Cell Line:3T3-L1 adipocytes Concentration:1, 10, and 100 μg/mL Incubation Time:8 days Result:Remarkably inhibited the accumulation of lipid droplets and adipogenesis by downregulating the expression of CCAAT-enhancer-binding protein α (C/EBPα), PPARγ, leptin and aP2. RT-PCR Cell Line:3T3-L1 adipocytes Concentration:1, 10, and 100 μg/mL Incubation Time:8 days Result:Inhibited the production of pro-inflammatory cytokines including TNF-α and IL-6, IL-1β and IL-18.

Animal Model:A dextran sulfate sodium (DSS)-induced mouse modelDosage:15 mg/kg or 30 mg/kg Administration:Oral administration; for 12 days Result:Significantly mitigated the DSS-induced body weight loss, attenuated the colon length shrinkage, and improved the disease index score. Successfully abrogated the DSS-induced IL-17 levels and improved the colonic barrier in colon tissues.

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Others

Antioxidant

Others

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3952-98-5

397.45

C10H16KNO9S2

>98% (HPLC)

In Vitro:?H2O : 12.5 mg/mL (31.45 mM)

C=CCC(=NOS(=O)(=O)[O-])SC1C(C(C(C(O1)CO)O)O)O.[K+]

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(-20℃)

With Ice Pack

≥ 2 years