Chlorin E6

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Chlorin e6 是一种光敏剂，在波长 402 和 662 nm 处有较强的吸收峰，在 668 nm 处表现出强烈的荧光。Chlorin e6 具有抗菌功效和抗癌活性。Chlorin e6 通过激活 caspase-3 诱导细胞凋亡，可用于癌症的研究。

Chlorin e6 is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer.

Western Blot Analysis Cell Line:AsPC-1 and MIA PaCa-2 Cells Concentration:5 μM, 10 μM Incubation Time:3 h Result:Significantly reduced Bcl-2 protein expression while increasing apoptotic molecule expression of Bax.Activated caspase-3 through its cleavage and upregulated the expression of cleaved PARP-1 in a dose-dependent manner.

Animal Model:B16F10 melanoma cells xenograft mouse, PANC02 pancreatic cells xenograft mouse Dosage:2.5 mg/kg Administration:Intravenous injection (i.v.)Result:Significantly reduced tumor volume.

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Microbiology/Virology

Parasite

Parasite

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19660-77-6

596.67

C34H36N4O6

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 20.83 mg/mL (34.91 mM; 超声助溶 )

CCc1c(C)c2cc3[nH]c(cc4nc([C@@H](CCC(O)=O)[C@@H]4C)c(CC(O)=O)c4[nH]c(cc1n2)c(C)c4C(O)=O)c(C)c3C=C

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(-20℃)

With Ice Pack

≥ 2 years