3-Sialyllactose sodium

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

3'-Sialyllactose (3'-SL) sodium 是一种益生元，具有维持免疫稳态，发挥抗炎和抗关节炎的作用。3'-Sialyllactose sodium 是毒性等级最低的普通碳水化合物，可用于炎症的研究。

3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation.

3'-Sialyllactose sodium (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines.3'-Sialyllactose sodium (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes.3'-Sialyllactose sodium (0-5000 μg/plate) shows no mutagenic effect with no evident growth inhibition and deposition in all strains in the presence or absence of metabolic activation.3'-Sialyllactose sodium (1250 μg/mL) induces no chromosomal aberrations and shows non-clastogenic effect in either the presence or absence of metabolic activation. Western Blot Analysis Cell Line:Chondrocytes Concentration:0, 50, 100 and 250 μM Incubation Time:24-36 hours Result:Dose-dependently increased Col2a1 transcript and protein levels, and restored Col2a1 expression in IL-1β-treated chondrocytes. Dose-dependently inhibited IL-1β-induced Mmp3, Mmp13 and Cox2 expression in chondrocytes. Reduced expression of Mmp3, Mmp13 and Cox2 induced by IL-6, IL-17 and TNF-α in chondrocytes.

3'-Sialyllactose sodium (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis.3'-Sialyllactose sodium (500, 1000 and 2000 mg/kg; oral administration; once) induces no micronuclei in the bone marrow cells of mice.3'-Sialyllactose sodium (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs.3'-Sialyllactose sodium shows a lethal dose (LD50) above 20 g/kg bw, the highest dose tested.Animal Model:8-week-old male C57BL/6 mice with medial meniscus surgery Dosage:10, 50 and 100 mg/kg Administration:Oral gavage; 10-100 mg/kg three times a week; for 6 weeks Result:Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression.

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Apoptosis

NF-κB

NF-κB

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128596-80-5

655.53

C23H38NNaO19

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 250 mg/mL (381.37 mM; 超声助溶)

[Na+].[H][C@@](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O[C@@]2(C[C@H](O)[C@@H](NC(C)=O)[C@@]([H])(O2)[C@H](O)[C@H](O)CO)C([O-])=O)[C@H]1O)([C@H](O)CO)[C@H](O)[C@@H](O)C=O

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(-20℃)

With Ice Pack

≥ 2 years