NF-κΒ activator 2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NF-κB activator 2 是一种有效的口服活性 NF-κB 激活剂，EC 50 为 1.58 μM。 NF-κB 激活剂 2 通过增加 NF-κB 表达和激活来诱导 SOD 2。 NF-κB激活剂2可用于肌萎缩侧索硬化症（ALS）的研究。

NF-κΒ activator 2 is a potent and orally active NF-κB activator, with an EC 50 of 1.58 μM. NF-κΒ activator 2 induces SOD 2 through increasing NF-κB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS) .(In Vitro):NF-κΒ activator 2 (compound 61) (1 μM, 6 h) induces SOD 2 mRNA expression in SH-SY5Y neuroblastoma cells . (In Vivo):NF-κΒ activator 2 (1 mg/kg; i.v.) displays a suitable half-life (0.96 h) in mice . NF-κΒ activator 2 (5 mg/kg; p.o.) displays a comparable half-life (2.86 h), oral bioavailability (15.6%), and C max (92 ng/mL) .

NF-κΒ activator 2 (compound 61) (1 μM, 6 h) induces SOD2 mRNA expression in SH-SY5Y neuroblastoma cells.

NF-κΒ activator 2 (1 mg/kg; i.v.) displays a suitable half-life (0.96 h) in mice.NF-κΒ activator 2 (5 mg/kg; p.o.) displays a comparable half-life (2.86 h), oral bioavailability (15.6%), and Cmax (92 ng/mL).

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Apoptosis

NF-κB

5-HT3

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2375281-44-8

298.27

C16H11FN2O3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (838.17 mM)

OC(c1cccc(-c2cnc(Nc(cccc3)c3F)o2)c1)=O

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(-20℃)

With Ice Pack

≥ 2 years