JNJ-DGAT2-A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

JNJ-DGAT2-A 是一种选择性、剂量依赖的二酰基甘油酰基转移酶 2 (DGAT2) 抑制剂，在表达人 DGAT2 的 Sf9 昆虫细胞膜中 IC50 值为 0.14 μM。JNJ-DGAT2-A 可用于甘油三酯 (TG) 合成的研究。

JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis.

JNJ-DGAT2-A (5 μM) inhibits about 99% of recombinant DGAT2 enzymatic activity.JNJ-DGAT2-A (5 μM) inhibits the DGAT activity in HepG2 cell lysates.JNJ-DGAT2-A (0.3125, 0.625, 1.25, 2.5, 5, 10, and 20 μM; 60 min prior to isotope-labeled and additional 2 h after isotope-labeled) dose-dependently inhibits the generation of TG (52:2), TG (54:3), and TG (50:2) using 13C3-D5-glycerol as a substrate in HepG2 cells with IC50 values of 0.85 μM, 0.99 μM, and 0.66 μM, respectively.

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Metabolic Enzyme/Protease

Transferase

Transferase

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1962931-71-0

523.38

C24H16BrFN4O2S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 3.33 mg/mL (6.36 mM; 超声助溶 (<60°C)

Fc1cc(\C=C2/SC(NCCc3ccccn3)=NC2=O)ccc1Oc1ccc(cc1Br)C#N

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(-20℃)

With Ice Pack

≥ 2 years