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INCB3619
CAS No. 791826-72-7
INCB3619 ( —— )
产品货号. M34284 CAS No. 791826-72-7
INCB3619 是一种选择性的，具有口服活性的 ADAM 抑制剂，作用于 ADAM10 和 ADAM17 的 IC50 值分别是 22 nM和 14 nM。INCB3619 具有抗肿瘤活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3069 | 有现货 |
|
| 10MG | ￥4019 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称INCB3619
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述INCB3619 是一种选择性的，具有口服活性的 ADAM 抑制剂，作用于 ADAM10 和 ADAM17 的 IC50 值分别是 22 nM和 14 nM。INCB3619 具有抗肿瘤活性。
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产品描述INCB3619 is a selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. INCB3619 has anti-tumor activity.
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体外实验Apoptosis Analysis.Cell Line:A549 cell Concentration:1, 10 μM Incubation Time:Result:Induced about 3% apoptosis at a concentration of 1 μM and about 5% at a concentration of 10 μM.Cell Viability Assay.Cell Line:NCI-H1666 cell Concentration:0-10 μM Incubation Time:72 h Result:Inhibited proliferation of NCI-H1666 cells.
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体内实验Animal Model:BALB/c nu/nu mouse model of A549 xenograft Dosage:50, 60 mg/kg Administration:subcutaneous injection, daily, 14 d Result:Significant tumor growth inhibition and delay at 60 mg/kg dose, less active effect at 50 mg/kg.
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同义词——
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通路Others
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靶点Other Targets
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受体Immunology/Inflammation related
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研究领域——
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适应症——
化学信息
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CAS Number791826-72-7
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分子量413.47
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分子式C22H27N3O5
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纯度>98% (HPLC)
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溶解度——
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SMILESC(NO)(=O)[C@H]1CC2(CN(C(OC)=O)[C@@H]1C(=O)N3CCC(=CC3)C4=CC=CC=C4)CC2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bin-Bing S Zhou, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006 Jul;10(1):39-50.?
产品手册
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