Emivirine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Emivirine (MKC-442) 是有效的非核苷逆转录酶的抑制剂 (NNRTIs)，对dTTP 和 dGTP 依赖性 DNA 或 RNA 聚合酶活性的 Ki 值分别为 0.20 和 0.01 μM。Emivirine 具有有效且选择性的抗 HIV-1 活性。

Emivirine (MKC-442) is a non-nucleoside reverse transcriptase inhibitors (NNRTIs) with Ki values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity.

Emivirine (EMV) is also specific for HIV-1 RT and was without effect on HIV-2.Emivirine (EMV) has no obvious toxicity for human healthy cells.:Cell Viability Assay Cell Line:Human bone marrow cells collected from normal healthy volunteers.Concentration:0, 0.1, 1, 10, or 100 μM.Incubation Time:14 days.Result:At concentrations of 0.1 to 10 μM, no effect on cell growth, lactic acid production, mitochondrial DNA synthesis, or mitochondrial structure was seen compared to what occurred with untreated HepG2 cells.

Tthe approximate lethal oral dose of Emivirine (EMV) for rats was ≥3 g/kg for males and 2.5 g/kg for females.Animal Model:Male Sprague-Dawley rats.Dosage:50 mg/kg.Administration:Gavage.Result:The oral absorption was 68%.

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Microbiology/Virology

HIV

HIV Protease

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149950-60-7

302.37

C17H22N2O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (330.72 mM; 超声助溶 )

C(C1=C(C(C)C)C(=O)NC(=O)N1COCC)C2=CC=CC=C2

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(-20℃)

With Ice Pack

≥ 2 years