LTGO-33 is a species-specific inhibitor of the voltage-gated sodium channel NaV1.8, inhibiting NaV1.8, NaV1.1-NaV1.7, and NaV1.9.LTGO-33 inhibits wild-type and multiple NaV1.8 variants associated with human pain disorders and can be used for the study of pain.hBChE-IN-2 is a low affinity Nurr1 agonist.

PF-05089771 free base 是一种有效的亚型选择性 Nav1.7 抑制剂，IC50 为 11 nM。

Veratridine 是一种在 Veratrumand Schoenocaulon 中发现的苯甲酸酯-cevane。它激活钠通道，使钠通道保持开放时间比正常情况更长。