AZD 7009 is a novel antiarrhythmic compound that inhibits the sodium current of hNav1.5 in CHO K1 cells with an IC50 of 11 uM. AZD 7009 inhibited late sodium current in isolated rabbit atrial and ventricular myocytes, and prolonged E-4031-induced action potential duration, promoting early post-depolarization of Purkinye fibers (EADs).

PF-05089771 free base 是一种有效的亚型选择性 Nav1.7 抑制剂，IC50 为 11 nM。

相对于其他钠通道亚型（>400 倍），VX-150 是一种高度选择性的 NaV1.8 抑制剂。