Hh-Ag1.5

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Hh-Ag1.5 (SAg1.5) 是一种有效的 Hedgehog (Hh) 激动剂，EC50 为 1 nM。Hh-Ag1.5 介导的重编程打破了非损伤肝脏干细胞的静止状态，从而挽救了肝衰竭。

Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure.

HhAg1.5 (5 μM; for 3 weeks) facilitates dramatic expansion of quiescent CD133+ CD45- liver stem cells (Hh3A cells) enriched from non-injured liver in vitro. Hh-Ag1.5 competely binds to the Smo-containing membranes with the Ki value of 0.52 nM.The Smo agonist SAG-1.5 displays nanomolar-range potency stimulation of Gli-responsive reporter activity, with an EC50 of 7 nM.

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GPCR/G Protein

Hedgehog (Hh)

Hedgehog/Smoothened

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612542-14-0

526.04

C28H26ClF2N3OS

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 50 mg/mL (95.05 mM; 超声助溶 )

CN[C@H]1CC[C@@H](CC1)N(Cc1cccc(c1)-c1ccncc1)C(=O)c1sc2c(F)ccc(F)c2c1Cl

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(-20℃)

With Ice Pack

≥ 2 years