Epiberberine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

表小檗碱可能是基于CYP2D6酶引起的药物相互作用。 Epiberberine 具有抗脂肪形成作用，是通过 3T3-L1 脂肪细胞分化过程中 Raf/MEK1/ERK1/2 和 AMPKα/Akt 通路的下调介导的。

Epiberberine may be caused drug interactions based on CYP2D6 enzyme. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte differentiation. 3. Epiberberine, as the brightest FSA emitter among the alkaloids, can also serve as an efficient conformation probe for HTG DNA and discriminate the DNA G-quadruplex from the RNA counterpart.

Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes, with an IC50 of 52.8 μM. Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation.Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner.

Epiberberine (225 mg/kg, p.o. daily for 40 days) reduces body weight, food consumption, water intake, and urinary output of KK-Ay mice.

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GPCR/G Protein

Hedgehog (Hh)

ERK1/2|MEK1

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6873-09-2

336.36

C20H18NO4+

>98% (HPLC)

In Vitro:?DMSO : 3.33 mg/mL (9.90 mM)

COC1=C(C=C2C(=C1)CC[N+]3=C2C=C4C=CC5=C(C4=C3)OCO5)OC

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(-20℃)

With Ice Pack

≥ 2 years