Seganserin, a non-selective 5-hydroxytryptamine 2-HT receptor antagonist, reversed the inhibitory effects of fluoxetine and quipazine on luteinizing hormone-induced hyperphagia, depression and nociception, and reversed the antidepressant and analgesic effects induced by fluoxetine and quipazine.

Eletriptan (UK 116044) 是一种有效的、选择性的、口服活性的 5-HT1B/1D 受体激动剂。

Lumateperone (ITI-007) 是一种有效的 5-HT2A 拮抗剂 (Ki=0.54 nM)、突触后 D2 拮抗剂 (Ki=32 nM) 和 SERT 阻滞剂 (Ki= 61 nM)。