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ATC 0175 hydrochloride
CAS No. 510733-97-8
ATC 0175 hydrochloride ( —— )
产品货号. M33831 CAS No. 510733-97-8
ATC0175 是一种有效的、选择性和口服活性的黑色素浓缩激素 1 受体拮抗剂，MCH1R 和 MCH2R 的 IC50s 分别为 13.5，>10000 nM。ATC0175 在动物模型中显示出抗抑郁作用和抗焦虑作用。ATC0175 具有研究抑郁症和/或焦虑症的潜力。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1729 | 有现货 |
|
| 10MG | ￥2774 | 有现货 |
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| 25MG | ￥4399 | 有现货 |
|
| 50MG | ￥6119 | 有现货 |
|
| 100MG | ￥7992 | 有现货 |
|
| 200MG | ￥10620 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ATC 0175 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ATC0175 是一种有效的、选择性和口服活性的黑色素浓缩激素 1 受体拮抗剂，MCH1R 和 MCH2R 的 IC50s 分别为 13.5，>10000 nM。ATC0175 在动物模型中显示出抗抑郁作用和抗焦虑作用。ATC0175 具有研究抑郁症和/或焦虑症的潜力。
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产品描述ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders.
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体外实验ATC0175 shows affinity for 5-HT2B and 5-HT1A with IC50s of 9.66 and 16.9 nM respectively.
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体内实验ATC0175 (1, 3, 10 mg/kg; p.o.) significantly and dose-dependently reduces immobility time, indicating antidepressant like potential.
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同义词——
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通路GPCR/G Protein
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靶点5-HT Receptor
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受体5-HT Receptor | GPR | Melanin-concentrating Hormone Receptor (MCHR)
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研究领域——
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适应症——
化学信息
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CAS Number510733-97-8
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分子量461.93
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分子式C23H26ClF2N5O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 12.5 mg/mL (27.06 mM; 超声助溶 (<60°C)
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SMILESN(C)(C)C=1C2=C(N=C(N[C@H]3CC[C@@H](NC(=O)C4=CC(F)=C(F)C=C4)CC3)N1)C=CC=C2.Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y. ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 2005 Winter;11(4):341-52.?
产品手册
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