ATC 0175 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ATC0175 是一种有效的、选择性和口服活性的黑色素浓缩激素 1 受体拮抗剂，MCH1R 和 MCH2R 的 IC50s 分别为 13.5，>10000 nM。ATC0175 在动物模型中显示出抗抑郁作用和抗焦虑作用。ATC0175 具有研究抑郁症和/或焦虑症的潜力。

ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders.

ATC0175 shows affinity for 5-HT2B and 5-HT1A with IC50s of 9.66 and 16.9 nM respectively.

ATC0175 (1, 3, 10 mg/kg; p.o.) significantly and dose-dependently reduces immobility time, indicating antidepressant like potential.

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GPCR/G Protein

5-HT Receptor

5-HT Receptor | GPR | Melanin-concentrating Hormone Receptor (MCHR)

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510733-97-8

461.93

C23H26ClF2N5O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 12.5 mg/mL (27.06 mM; 超声助溶 (<60°C)

N(C)(C)C=1C2=C(N=C(N[C@H]3CC[C@@H](NC(=O)C4=CC(F)=C(F)C=C4)CC3)N1)C=CC=C2.Cl

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(-20℃)

With Ice Pack

≥ 2 years