Indomethacin sodium hydrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Indomethacin (Indometacin) sodium hydrateis 是一种有效的口服活性 COX1/2抑制剂，COX-1 和 COX-2 的IC50 值分别为 18 nM 和 26 nM。Indomethacin sodium hydrateis 具有抗癌和抗感染活性。Indomethacin sodium hydrateis 可用于癌症、炎症和病毒感染的研究。

Indomethacin (Indometacin) sodium hydrateis a potent, orally active COX1/2inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium hydrateis has anticancer activity and anti-infective activity. Indomethacin sodium hydrateis can be used for cancer, inflammation and viral infection research.

Cell Viability Assay Cell Line:3LL-D122 cells (highly metastatic variant of mouse LLcarcinoma cells) Concentration:0, 20, 50, 100 and 150μM Incubation Time:24 hours Result:Inhibited cell viability at 20 mM, with 50% inhibition at 60 mM.Cell Cycle Analysis Cell Line:3LL-D122 cells (highly metastatic variant of mouse LLcarcinoma cells) Concentration:0, 30 and 80μM Incubation Time:24 hours Result:Decreased in the percentage of cells at the G2/M phase and increased in the percentage of cells at G1 phase.

Animal Model:Male Sprague-Dawley ratsDosage:0.01-10 mg/kg Administration:Oral administration; for 3 hoursResult:Inhibited the carrageenan-induced rat paw oedema (ED50=2.0?mg/kg) and hyperalgesia (ED50=1.5?mg/kg) in a dose-dependent manner.Animal Model:Male C57BL/6J mice Dosage:10 mg/mL Administration:Oral administration; daily, for 29 days Result:Delayed the onset of tumor growth and the initial growth rate of the footpad tumors.

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Chromatin/Epigenetic

COX

COX

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74252-25-8

433.82

C19H21ClNNaO7

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 25 mg/mL (57.63 mM; 超声助溶) DMSO 中的溶解度 : 12.5 mg/mL (28.81 mM; 超声助溶 (<60°C)

O=C([O-])CC1=C(N(C2=C1C=C(OC)C=C2)C(C3=CC=C(Cl)C=C3)=O)C.[Na+].O.O.O

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(-20℃)

With Ice Pack

≥ 2 years