P32/98 hemifumarate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

P32/98 hemifumarate 是一种二肽基肽酶 IV (DPP4) 抑制剂。P32/98 hemifumarate 在 Zucker 糖尿病大鼠模型中可改善葡萄糖耐量、胰岛素敏感性和 β 细胞反应性。

P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model.

GLP-1 acts function of stimulation of glucose dependent insulin secretion and induction of satiety feelings, and DPPIV is the major renal catabolic pathway for GLP-1 in vivo.P32/98 hemifumarate, together with 200 pM GLP-1, (10 μM; 3 h) shows no significant inhibition of sodium re-absorption in porcine proximal tubular cells.P32/98 hemifumarate (10 μM; 96 h) does not influence the mRNA expression of GLP-1R, DPPIV, Na+/H+ exchanger isoform 3 (NHE3), sodium-dependent glucose transporter slc5a1, slc5a2 (SGLT1, 2).Cell Cytotoxicity Assay Cell Line:Porcine proximal tubular cells Concentration:10 μM Incubation Time:96 hours Result:Showed no toxic.

P32/98 hemifumarate (25 mg/kg; i.g.; once daily) long-time treatment significantly improves the glucose tolerance in Zucker diabetic fatty rats, a model of IGT (impaired glucose tolerance).Animal Model:Zucker diabetic fatty rat Dosage:25 mg/kg Administration:Oral gavage; once daily Result:Significantly improved the glucose tolerance in Zucker diabetic fatty rats.

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Metabolic Enzyme/Protease

DPP

DPP-4

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251572-86-8

520.71

C22H40N4O6S2

>98% (HPLC)

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OC(/C=C/C(O)=O)=O.CC[C@H](C)[C@H](N)C(N1CCSC1)=O.CC[C@H](C)[C@H](N)C(N2CCSC2)=O

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(-20℃)

With Ice Pack

≥ 2 years