Anisodamine B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Anisodamine (6-Hydroxyhyoscyamine)，颠茄生物碱，也是一种非亚型的选择性毒蕈碱和烟碱类胆碱受体拮抗剂。Anisodamine 用于中医研究多种疾病，主要用于改善休克状态下的微循环，也可用于有机磷中毒。

Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning.

Anisodamine (100 μg/mL; 20 minutes; RAW264.7 cells) pretreatment for 20 minutes before Ach results in significantly attenuates average fluorescence intensity of α-bungarotoxin binding compared with Ach alone.Anisodamine action might be through blockade of muscarinic receptors and thus allowing more endogenous ACh binding to the α-7nAChR.

Anisodamine (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%.Animal Model:LPS-Induced Shock Mice Dosage:50 mg/kg Administration:I.p.Result:Markedly decreased the mortality to 20%.

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Cell Cycle/DNA Damage

AChR

AChR

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55869-99-3

305.37

C17H23NO4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 100 mg/mL (327.47 mM ) H2O 中的溶解度 : 20 mg/mL (65.49 mM; 超声助溶)

CN1[C@@H]2C[C@H](O)[C@H]1C[C@H](C2)OC(=O)[C@H](CO)c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years