suvn-911

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

suvn-911 是一种有效的选择性神经元烟碱乙酰胆碱 α4β2 受体 (Ki = 1.5 nM) 拮抗剂，具有抗抑郁活性。

suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.(In Vitro):suvn-911 shows good selectivity against over 70 receptors which includes GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors, and prostaglandins. suvn-911 displays high selectivity for α4β2 over α3β4 nAChR.(In Vivo):In male Wistar rats, suvn-911 (1.0-10.0 mg/kg; p.o.) showed significant antidepressant-like activity with no signs of tachyphylaxis. suvn-911 (3 mg/kg; p.o.) showed high oral exposures, longer half-lives(T1/2 = 3.34 hr), and adequate brain penetration in Wistar rats. suvn-911 showed metabolic stability and no cardiovascular and gastrointestinal side effects.

SUVN-911 displays high selectivity for α4β2 over α3β4 nAChR.SUVN-911 shows good selectivity against over 70 receptors which includes GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors and prostaglandins.

SUVN-911 is devoid of cardiovascular and gastrointestinal side effects.SUVN-911 (1.0-10.0 mg/kg; p.o.; daily; for 3 days) shows significant antidepressant effects.SUVN-911 shows metabolic stability in rats.SUVN-911 (3 mg/kg; p.o.) has shown high oral exposures, longer half-lives and adequate brain penetration in Wistar rats. Animal Model:Male Wistar rats (180-230 g)Dosage:1 mg/kg, 3 mg/kg, 10.0 mg/kg Administration:Oral administration, daily, for 3 days Result:Showed anti depressant like activity with no signs of tachyphylaxis.Animal Model:Male Wistar rats (225 ± 25 g) Dosage:3 mg/kg (Pharmacokinetic Analysis) Administration:Oral administration Result:AUC=3507 ng*h/mL, T1/2=3.34 hours.

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Cell Cycle/DNA Damage

AChR

5-HT6

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2414674-71-6

224.69

C11H13ClN2O

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (478.65 mM)

ClC1=CC=C(OC[C@H]2N[C@H](C3)[C@H]3C2)C=N1

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(-20℃)

With Ice Pack

≥ 2 years