Tetrahydrofolic acid

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Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) 是一种具有生物活性的维生素 B9 叶酸衍生物，是氨基酸，核酸和脂质的一个碳原子的供体。Tetrahydrofolic acid用作游离甲醛的受体，产生 5,10-亚甲基四氢叶酸-四氢叶酸。

Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid.

Cell Viability Assay Cell Line:Adh5-/- DT40 cells Concentration:0-200 μM Incubation Time:3 days Result:Viability of Adh5-/- DT40 cells rapidly dropped. Western Blot Analysis Cell Line:Adh5-/- DT40 cells Concentration: 0-200 μM Incubation Time:16 hours Result:Strongly promoted FANCD2 and ser139-H2AX focus formation in Adh5-/- cells in a dose-dependent manner.

Animal Model:Adh5-/- mice Dosage:62.5 mg/kg Administration:Intraperitoneal injection; daily Result:Perturbed hematopoiesis, increased ser139-H2AX phosphorylation, and decreased the survival of progenitor cells (HSPCs).

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Proteasome/Ubiquitin

Endogenous Metabolite

Endogenous Metabolite

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135-16-0

445.43

C19H23N7O6

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 20.83 mg/mL (46.76 mM; 超声助溶 )

Nc1nc2NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Nc2c(=O)[nH]1

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(-20℃)

With Ice Pack

≥ 2 years