5'-Methylthioadenosine ( Methylthioadenosine | 5'-(Methylthio)-5'-deoxyadenosine | 5'-Deoxy-5'-(methylthio)adenosine | 5'-S-Methyl-5'-thioadenosine )

产品货号. M21415 CAS No. 2457-80-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

5'-Methylthioadenosine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

5'-甲硫腺苷由 S-腺苷甲硫氨酸产生，是一种强大的抑制产物。
产品描述

5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product.
体外实验

Cell Viability Assay Cell Line:MTAP+ and MTAP? NIH3T3 cells, isogenic MTAP+ and MTAP? cell line derived from a human HT1080 fibrosarcoma cell line Concentration:6TG and 2FA in combination with 10 μM MTA Incubation Time:48 hours Result:Significantly increased IC50 concentration in MTAP+ cells, but no significant change in MTAP? cells.
体内实验

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同义词

Methylthioadenosine | 5'-(Methylthio)-5'-deoxyadenosine | 5'-Deoxy-5'-(methylthio)adenosine | 5'-S-Methyl-5'-thioadenosine
通路

Proteasome/Ubiquitin
靶点

Endogenous Metabolite
受体

Human Endogenous Metabolite
研究领域

——
适应症

——

CAS Number

2457-80-9
分子量

297.33
分子式

C11H15N5O3S
纯度

>98% (HPLC)
溶解度

DMSO:5 mg/mL (168.16 mM);DMF:2.5 mg/mL (8.41 mM);H2O:1 mg/mL (3.36 mM)
SMILES

CSC[C@H]([C@H]([C@H]1O)O)O[C@H]1n1c2ncnc(N)c2nc1
化学全称

(2R3R4S5S)-2-(6-amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-34-diol

1.Avila MA et al. Methylthioadenosine. Int J Biochem Cell Biol. 2004 Nov;36(11):2125-30.

计算器

产品手册

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