DL-3-AMINOISOBUTYRIC ACID

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

β-氨基异丁酸是 N-氨甲酰-β-氨基异丁酸被β-脲基丙酸酶 (EC 3.5.1.6) 转化的产物，这是嘧啶降解的最后一步。 β-脲基丙酸酶缺乏症是与神经系统异常相关的嘧啶降解的先天性错误。

beta-aminoisobutyric acid is the product from the conversion of N-carbamyl-beta-aminoisobutyric acid by the enzyme Beta-ureidopropionase (EC 3.5.1.6) the last step in pyrimidine degradation. Beta-ureidopropionase deficiency is an inborn error of pyrimidine degradation associated with neurological abnormalities.

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Weight is slightly decreased in the mice by the end of 3-Amino-2-methylpropanoic acid (BAIBA) treatment. Analysis of body composition using MRI demonstrates BAIBA treatment significantly decreases body fat in the mice. Consistent with the effects on thermogenic and β-oxidation gene expression and body weights, analysis with metabolic cages indicates that oxygen consumption (VO2) and whole body energy expenditure are increased in the BAIBA treated mice without any significant difference in activity or food intake. The mice are also challenged with an intraperitoneal glucose tolerance test (IPGTT). BAIBA is found to significantly improve the glucose tolerance in the mice as determined by the area under the curve of the IPGTT.

3-Amino-2-methylpropanoic acid | α-Methyl-β-alanine

Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite

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144-90-1

103.12

C4H9NO2

>98% (HPLC)

DMSO:10 mM

CC(CN)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years