NO-prednisolone ( —— )

产品货号. M33613 CAS No. 327610-87-7

NO-prednisolone 是释放一氧化氮 (NO) 的 Prednisolone 衍生物。NO-prednisolone 有效刺激体内 IL-10 产生。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥943	有现货
10MG	￥1482	有现货
25MG	￥2306	有现货
50MG	￥3060	有现货
100MG	￥4077	有现货
200MG	￥5481	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥1121	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

NO-prednisolone
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NO-prednisolone 是释放一氧化氮 (NO) 的 Prednisolone 衍生物。NO-prednisolone 有效刺激体内 IL-10 产生。
产品描述

NO-prednisolone is a nitric oxide (NO)-releasing derivative of Prednisolone.NO-prednisolone potently stimulates IL-10 production in vivo.
体外实验

NO-prednisolone (NCX-1015), an NO-releasing derivative of Prednisolone, is demonstrated to be more effective than Prednisolone in reducing inflammation, inhibiting cytokine and chemokine generation, and up-regulating the expression of the steroid-sensitive cell-surface marker CD163 in human peripheral blood mononuclear cellsIncubation of PBMCs with NO-prednisolone (NCX-1015) and Prednisolone produces a concentration-dependent activation of CD163. NO-prednisolone is more potent than Prednisolone at inducing CD163 cell surface expression. The increased efficacy of NO-prednisolone, compared with the parent molecule Prednisolone, is also observed when assessing inhibition of LPS induced IL-1β production.
体内实验

In vivo treatment with NO-prednisolone (NCX-1015) potently stimulates IL-10 production, suggesting that the NO steroid induces a regulatory subset of T cells that negatively modulates intestinal inflammation. The two doses of NO-prednisolone tested, 0.5 and 5 mg/kg/day (equivalent to 0.33 and 3.3 mg/kg/day prednisone, respectively) effectively attenuates the severity of the wasting syndrome, ameliorates the colitis score, and reduces the colonic myeloperoxidase (MPO) activity. NO-prednisolone administration also reduces the colonic mRNA and protein content of tumor necrosis factor-α, IL-12, and IFN-γ. NO-prednisolone also reduces the expression of inducible NO synthase and cyclooxygenase-2 but in contrast does not inhibit colonic expression of IL-10 mRNA or protein. In fact, IL-10 expression is enhanced in mice treated with NO-prednisolone.
同义词

——
通路

Apoptosis
靶点

IL Receptor
受体

IL Receptor
研究领域

——
适应症

——

化学信息

CAS Number

327610-87-7
分子量

539.57
分子式

C29H33NO9
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO 中的溶解度 : 25 mg/mL (46.33 mM; 超声助溶 (<60°C)
SMILES

[H][C@@]12CC[C@](O)(C(=O)COC(=O)c3ccc(CO[N+]([O-])=O)cc3)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Fiorucci S, et al. NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15770-?

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册