PBOX 6

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PBOX 6 是一种 pyrrolo-1,5-benzoxazepine (PBOX) 化合物，可作为微管解聚剂和促凋亡剂起作用。

PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule-depolymerizing agent and an apoptotic agent.

PBOX 6 is a potent apoptotic PBOX, but does not elicit a general toxic effect in a rat R2C Leydig cell line. PBOX 6 (0-25 μM, 16 h) results in dose- and time-dependent induction of apoptosis, and also causes DNA fragmentation at 10 μM in HL-60 cells. PBOX 6 (10 μM) induces apoptosis through activation of caspase 3-like proteases in HL-60 cells. PBOX 6 (10 μM) induces apoptosis and exerts an accumulation of cytochromec in the cytosol, but this effect is not triggered by oxidative stress, and is independent of peripheral-type benzodiazepine receptor (PBR) and NF-κB. PBOX 6 (25 μM) induces apoptosis in MCF-7 cells through activation of caspase-7. PBOX 6 (10 μM) induces the redistribution of cypA from the nucleus to the cytosol of the cell in K562 cells. PBOX 6 (10 μM) induces nucleocytoplasmic redistribution of cypA and pin1 through a JNK-dependent manner, also dependent on upstream activation of a trypsin-like serine protease, and this effect correlates with G2/M arrest in K562 cells.

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Apoptosis

Apoptosis

Apoptosis

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290814-68-5

396.44

C25H20N2O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 33.33 mg/mL (84.07 mM; 超声助溶 )

CN(C)C(=O)OC1=C(Oc2ccccc2-n2cccc12)c1cccc2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years