D609

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

D609 是一种抗肿瘤黄原酸盐，一种特异性、竞争性的磷脂酰胆碱特异性磷脂酶 C (PC-PLC) 抑制剂，Ki 为 6.4 μM。D609 是一种抗氧化保护剂，也具有抗病毒和抗炎活性。

D609, an antitumoural xanthate, is a specific and competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor with a Ki of 6.4 μM. D609 is an antioxidative protector and has antiviral and anti-inflammatory activity.

Cell Proliferation AssayCell Line:RAW 264.7 macrophages, N9 and BV-2 microglia, and DITNC1 astrocytes,Concentration:100 μM Incubation Time:For 2 hoursResult:Significantly attenuated the proliferation of RAW 264.7 macrophages, N9 and BV-2 microglia, and DITNC1 astrocytes, without affecting cell viability.Apoptosis Analysis Cell Line:BV-2 cells Concentration:50, 100 and 200 μM Incubation Time:For 2 hours Result:Activated caspase-3 in a dose- and time-dependent manner. Cell Cycle Analysis Cell Line:BV-2 cells Concentration:100 μM Incubation Time:For 2 hours Result:Significantly inhibited BrdU incorporation in BV-2 microglia and caused accumulation of cells in G1 phase with decreased number of cells in the S phase.Western Blot Analysis Cell Line:BV-2 cells Concentration:100 μM Incubation Time:For 2 hours Result:Increased ceramide levels, up-regulated p21 expression and causes a decreased in phospho-Rb.

Animal Model:26-week-old apoE?/? and C57BL/6 WT mice Dosage:2.5, 10 mg/kg Administration:IP; per day for 6 weeks Result:Inhibited the progression of preexisting atherosclerotic lesions in apoE?/? mice and changed the lesion composition into a more stable phenotype. Significantly decreased the aortic endothelial expression of the vascular cell adhesion molecule-1 and the intercellular adhesion molecule-1.

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Apoptosis

Apoptosis

Apoptosis | Antioxidant

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83373-60-8

266.46

C11H15KOS2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (375.29 mM; 超声助溶 ) H2O 中的溶解度 : 2 mg/mL (7.51 mM; 超声助溶)

SC(=S)OC1CC2CC1C1CCCC21

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(-20℃)

With Ice Pack

≥ 2 years