Chloroquinoxaline sulfonamide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Chloroquinoxaline sulfonamide (Chloroquinoxaline) 是 sulfaquinoxaline 的结构类似物，是拓扑异构酶 II alpha/beta (topoisomerase II alpha/beta) 毒物。Chloroquinoxaline sulfonamide 用于控制家禽，兔，绵羊和牛的球虫病。 具有抗肿瘤活性。

Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle. Antitumor activity.

The Chloroquinoxaline sulfonamide IC50?for CV-1cells, obtained using an MTT cytotoxicity assay, was 1.8 mM. Chloroquinoxaline sulfonamide causes dose-dependent protein-DNA cross-links to CV-1 monkey kidney cell chromosomal DNA when drug treatment was terminated by lysis with GuHCl. Chloroquinoxaline sulfonamide-induced protein-DNA cross-links in CV-1 cells. Chloroquinoxaline sulfonamide-induced topoisomerase II-DNA cross-links.Chloroquinoxaline sulfonamide (Chloroquinoxaline), a chlorinated derivative of sulfaquinoxaline, inhibits proliferation of murine B16 melanoma cells, but only when relatively high drug concentrations (1 mM) are used.Cell Proliferation Assay Cell Line:B16 murine melanoma cells Concentration:10 μM, 100 μM, 1 mM Incubation Time:24, 48, 72 hours Result:Inhibited proliferation of murine B16 melanoma cells, but only when relatively high drug concentrations (1 mM) were used.

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Cell Cycle/DNA Damage

Topoisomerase

Topoisomerase

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97919-22-7

334.78

C14H11ClN4O2S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (373.38 mM; 超声助溶 )

Nc1ccc(cc1)S(=O)(=O)Nc1cnc2c(Cl)cccc2n1

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(-20℃)

With Ice Pack

≥ 2 years