Indotecan

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Indotecan 是拓扑异构酶 1 (Top1) 的有效抑制剂。

Indotecan is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).

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Animal Model:Female BALB/c mice (4-6 weeks) were infected with metacyclic parasites intravenously through the tail vein Dosage:2.5 mg/kg body weight per injection Administration:Intraperitoneally every 2 days for 15 days (total, eight doses)Result:A drastic reduction of the number of transforming amastigotes recovered from the target organs of drug-treated animals was observed.

LMP-400 | NSC-724998

Cell Cycle/DNA Damage

Topoisomerase

topoisomerase I

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915303-09-2

478.49

C26H26N2O7

>98% (HPLC)

In Vitro:?DMSO : < 1 mg/mL (insoluble o)

O=C1N(CCCN2CCOCC2)C3=C(C(C4=C3C=C(OCO5)C5=C4)=O)C6=C1C=C(OC)C(OC)=C6

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(-20℃)

With Ice Pack

≥ 2 years