Idarubicin hydrochloride ( 4-Demethoxydaunorubicin hydrochloride )

产品货号. M15119 CAS No. 57852-57-0

一种蒽环类抗白血病化合物，可插入 DNA 并通过干扰癌细胞中的拓扑异构酶 II 来防止 DNA 解旋。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥405	有现货
10MG	￥649	有现货
25MG	￥1051	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥466	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Idarubicin hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种蒽环类抗白血病化合物，可插入 DNA 并通过干扰癌细胞中的拓扑异构酶 II 来防止 DNA 解旋。
产品描述

An anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells; inhibits the proliferation of MCF-7 cells with IC50 of 0.1 uM; also induces histone eviction from chromatin.Chemotherapeutic Agents Approved(In Vitro):The IC50 of idarubicin is 3.3±0.4 ng/mL on MCF-7 monolayers and 7.9±1.1 ng/mL in multicellular spheroids. Idarubicin has shown a greater cytotoxicity than daunorubicin or doxorubicin in various in vitro systems. This has been attributed to a better ability of idarubicin to induce the formation of topoisomerase II -mediated DNA breaks.Idarubicin is about 57.5-fold and 25-fold more active than doxorubicin and epirubicin, respectively. Idarubicin produces a concentration-dependent reduction in cell growth, with an IC50 value of approximately 0.01 μM. Idarubicin produced a concentration-dependent inhibition of DNA synthesis.
体外实验

The IC50 of Idarubicin hydrochloride is 3.3±0.4 ng/mL on MCF-7 monolayers and 7.9±1.1 ng/mL in multicellular spheroids. Idarubicin hydrochloride has shown a greater cytotoxicity than daunorubicin or doxorubicin in various in vitro systems. This has been attributed to a better ability of idarubicin to induce the formation of topoisomerase II -mediated DNA breaks. Idarubicin hydrochloride is about 57.5-fold and 25-fold more active than doxorubicin and epirubicin, respectively. Idarubicin hydrochloride produces a concentration-dependent reduction in cell growth, with an IC50 value of approximately 0.01 μM. Idarubicin hydrochloride produced a concentration-dependent inhibition of DNA synthesis.
体内实验

——
同义词

4-Demethoxydaunorubicin hydrochloride
通路

Cell Cycle/DNA Damage
靶点

Topoisomerase
受体

Multicellular spheroids| Topo II (MCF-7 cells)
研究领域

Cancer
适应症

Chemotherapeutic

化学信息

CAS Number

57852-57-0
分子量

533.9548
分子式

C26H28ClNO9
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

O=C1C2=C(O)C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@](O)(C(C)=O)C4)=C4C(O)=C2C(C5=C1C=CC=C5)=O.[H]Cl
化学全称

5,12-Naphthacenedione, 9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, hydrochloride (1:1), (7S,9S)-

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Gewirtz DA, et al. Cancer Chemother Pharmacol. 1998;41(5):361-9. 2. Pang B, et al. Nat Commun. 2013;4:1908. 3. Nitiss JL. Nat Rev Cancer. 2009 May;9(5):338-50.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册