Abaperidone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Abaperidone 是一种有效的 5-HT2A 受体和多巴胺 D2 受体拮抗剂，IC50 分别为 6.2 和 17 nM。

Abaperidone is a potent antagonist of 5-HT2A?receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM.

Abaperidone possesses good affinity for dopamine D2 receptors, together with a greater affinity for 5-HT2 receptors with IC50 of17and 6.2 nM, reaspectively.

The time course of the inhibition of climbing behavior for a period of several hours after oral administration of either 0.5 mg/kg of Abaperidone or risperidone is tested in mice. Also is included a comparative test of catalepsy induced by Abaperidone and risperidone along several hours following oral administration at several doses in rats. A somewhat lesser induction of catalepsy is observed for Abaperidone. A study of serum prolactin levels after oral administration of Abaperidone, haloperidol, and risperidone at 5 mg/kg for either 1 or 3 days in rats. Increases in prolactin levels after oral administration of Abaperidone are smaller than those for reference drugs.

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GPCR/G Protein

Dopamine Receptor

Dopamine Receptor | 5-HT Receptor

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183849-43-6

452.47

C25H25FN2O5

>98% (HPLC)

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FC=1C=C2C(C(=NO2)C3CCN(CCCOC=4C=C5C(=CC4)C(=O)C(CO)=CO5)CC3)=CC1

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(-20℃)

With Ice Pack

≥ 2 years