DOPEXAMINE

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Dopexamine 是一种多巴胺能激动剂，Dopexamine 盐酸盐具有有趣的血管舒张特性，对 β2 肾上腺素受体具有显着的内在激动剂活性，而对多巴胺能受体（DA1 和 DA2）具有较低的激动剂活性。

Dopexamine is a dopaminergic agonistDopexamine hydrochloride has interesting vasodilator properties, with marked intrinsic agonist activity at beta-2 adrenoreceptors and a lesser agonist activity at dopaminergic receptors (DA1 and DA2).?Dopexamine hydrochloride is responsible for an inhibition of neuronal re-uptake of catecholamines (uptake-1), producing an indirect stimulation of cardiac beta 1-receptors.?Dopexamine hydrochloride improves cardiac performance by a marked vasodilation and a mild inotropic activity.?The specific activity at dopaminergic receptors increases cerebral, myocardial, splanchnic and renal blood flows.?These haemodynamic effects are associated with an increase in diuresis and natriuresis.?These benefits are achieved without side effects such as an increased myocardial oxygen consumption, although induced tachycardia may be responsible for chest pain/anginae pain in patients with ischaemic heart disease.

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GPCR/G Protein

Dopamine Receptor

Dopamine

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86197-47-9

356.5

C22H32N2O2

>98% (HPLC)

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Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O

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(-20℃)

With Ice Pack

≥ 2 years