NUCC-390

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NUCC-390 是新型的选择性小分子 CXCR4 receptor 受体激动剂。NUCC-390 可以诱导 CXCR4 受体的内化，作用方式与 AMD3100 (HY-10046) 相反。NUCC-390 在动物模型中，有助于神经退行性变后神经功能恢复。

NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046). NUCC-390 promotes nerve recovery of function after neurodegeneration in vivo.

NUCC-390 (10 μM) produces strong (Ca)i response, but this effect can be blocked by the known potent and selective CXCR4 antagonist AMD3100.NUCC-390 (10 μM; pre-treatment 30 mins) leads to increased levels of pERK, it has the capability of stimulating signaling activity downstream of CXCR4 receptors.NUCC-390 (10 μM; 2 hours) can induce CXCR4 receptor internalization, and non-treated cells exhibit some diffuse expression of CXCR4-YFP throughout the cytosol and clear expression in the cell membrane in HEK cells.NUCC-390 (0-1.25 μM; 24 hours) boosts axonal growth in cultured cerebellar granule neurons (CGNs) via CXCR4.Western Blot Analysis Cell Line:C8161 cells?Concentration:10 μM Incubation Time:Pre-treated 30 mins Result:Increased the level of pERK.Cell Proliferation Assay Cell Line:Cerebellar granule neurons (CGNs) Concentration:0 μM; 0.0625 μM; 0.25 μM; 1.25 μM Incubation Time:24 hours Result:Stimulated axonal growth via CXCR4.

NUCC-390 (hind limb injection; 3.2 mg/kg; twice daily; 3 days) contributes to the functional and anatomical recovery of the neuromuscular junction (NMJ) following an acute nerve terminal damage by α-LTx in CD-1 mice.Animal Model:Six to eight-week-old CD1 mice Dosage:3.2 mg/kg Administration:Hind limb injection; twice daily; 3 days Result:Promoted functional and anatomical recovery of the NMJ.

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Autophagy

CXCR

CXCR

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1060524-97-1

395.54

C23H33N5O

>98% (HPLC)

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C(=O)(C=1C2=C(N(CCC)N1)CCC(NCCC=3C=CN=CC3)C2)N4CCCCC4

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(-20℃)

With Ice Pack

≥ 2 years