021-51111890
购物车（）
sales@molnova.cn
CPUY074020
CAS No. 902279-44-1
CPUY074020 ( —— )
产品货号. M32863 CAS No. 902279-44-1
CPUY074020 是一种高效、有口服活性的组蛋白甲基转移酶 G9a 抑制剂，其 IC50 值为 2.18 μM。CPUY074020 具有抗增殖活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥979 | 有现货 |
|
| 10MG | ￥1454 | 有现货 |
|
| 25MG | ￥2297 | 有现货 |
|
| 50MG | ￥3162 | 有现货 |
|
| 100MG | ￥4140 | 有现货 |
|
| 200MG | ￥5328 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称CPUY074020
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述CPUY074020 是一种高效、有口服活性的组蛋白甲基转移酶 G9a 抑制剂，其 IC50 值为 2.18 μM。CPUY074020 具有抗增殖活性。
-
产品描述CPUY074020 is a potent and oral bioavailable inhibitor of histone methyltransferase G9a, with an IC50 of 2.18 μM. CPUY074020 possesses anti-proliferative activity.
-
体外实验CPUY074020 (2-8μM; 24 hours) induces cell death through apoptosis.CPUY074020 (2.5-10μM ; 48 hours) dose-dependently de-regulates H3K9 trimethylation.Apoptosis Analysis Cell Line:MCF-7 cells Concentration:2 μM, 4 μM, 8 μM Incubation Time:24 hours Result:Induced MCF-7 cells apoptosis.Western Blot Analysis Cell Line: MCF-7 cells Concentration:2.5 μM, 5 μM, 10 μM Incubation Time:48 hours Result:Dose-dependently de-regulated H3K9 trimethylation.
-
体内实验CPUY074020 exhibits reasonable PK properties, with an oral bioavailability of 55.5% and a T1/2 value of 4.0 hours at an oral dose of 10 mg/kg.Animal Model:Mice Dosage:10 mg/kg Administration:Oral administration Result:t1/2=4.0 hours
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体Histone Methyltransferase
-
研究领域——
-
适应症——
化学信息
-
CAS Number902279-44-1
-
分子量416.52
-
分子式C25H28N4O2
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESN(CCN1CCCC1)C2=C3C=4C(C(=C2)N5CCCCC5)=NOC4C=6C(C3=O)=CC=CC6
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Chen WL, et al. Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular. Bioorg Med Chem. 2016 Nov 15;24(22):6102-6108.?
产品手册
关联产品
-
4-Methoxycinnamyl al...
4-Methoxycinnamyl alcohol showed toxicity to MCF-7, HeLa and DU145 cancer cell lines with IC50 values of 14.24, 7.82 and 22.10 μg/mL, respectively. 4-Methoxycinnamyl alcohol was isolated from Foeniculum vulgare. 4-Methoxycinnamyl alcohol did not show apoptotic effects but showed necrosis after 48 h in a 10 μg/mL DNA fragmentation study.
-
TAT TFA
TAT TFA (YGRKKRRQRRR) is derived from human immunodeficiency virus (hiv-1) transcription reverse activator TAT, is a cell penetrating peptide.
-
3β-Ursodeoxycholic a...
3β-Ursodeoxycholic acid (Isoursodeoxycholic acid)是胆汁酸。 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid)通过口服给药显示出良好的耐受性和良好的肠道吸收。3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) 可以被肠和肝酶异构化并产生 UDCA。
