AP39 free base is a mitochondrial-targeted H(2)S donor that can improve the survival rate of porcine islets in culture. AP39 free base regulates mitophagy through the AMPK-ULK1-FUNDC1 pathway, inhibits cell pyroptosis, and improves doxorubicin-induced myocardial fibrosis.

Cubebin showes anti-inflammatory, and anticancer activities. It also shows neuroprotective effects, this could be attributed to its brain AChE inhibition and antioxidant activity.

CRT0044876 是一种有效的选择性 APE1 抑制剂，IC50 约为 3 μM。