[Nphe1]Nociceptin(1-13)NH2 ( —— )

产品货号. M30624 CAS No. 267234-08-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

[Nphe1]Nociceptin(1-13)NH2
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo.
产品描述

Selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo.
体外实验

[Nphe1]nociceptin(1-13)NH2?binds selectively to recombinant nociceptin receptors expressed in Chinese hamster ovary (CHO) cells (pKi=8.4) and competitively antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0).
体内实验

——
同义词

——
通路

Endocrinology/Hormones
靶点

Opioid Receptor
受体

——
研究领域

——
适应症

——

CAS Number

267234-08-2
分子量

1381.6
分子式

C61H100N22O15
纯度

>98% (HPLC)
溶解度

10% acetonitrile:1 mg/mL
SMILES

[H]N(CC(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O)CC1=CC=CC=C1
化学全称

——

1. Calo et al (2000) Characterization of [Nphe1]nociceptin(1-13)NH2, a new selective nociceptin receptor antagonist. Br.J.Pharmacol. 129 1183 PMID:

计算器

产品手册

关联产品

Orphanin FQ (1-11)

Peptide fragment containing amino acids 1-11 of Nociceptin. Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays analgesic properties in CD-1 mice.
6-GNTI dihydrochlori...

6'-GNTI dihydrochloride ，一种 κ-阿片受体 (KOR) 激动剂，在 β-arrestin2 募集过程中，显示出对 G 蛋白介导的信号激活的偏向。6'-GNTI dihydrochloride 只激活纹状体神经元的 Akt 通路。
EST73502

EST73502 是 μ-阿片受体 (Ki = 64 nM) 激动剂和 σ1 受体 (Ki = 118 nM) 拮抗剂。 EST73502 显示抗伤害活性。