Naloxone hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

盐酸纳洛酮是一种阿片类反激动剂化合物，用于对抗阿片类化合物过量的影响。

Naloxone hydrochloride is an opioid inverse agonist drug used to counter the effects of opiate overdose.

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Naloxone (2.0 mg/kg with constant infusion of 1.7 mg/kg/h) causes a significant improvement in neurobehavioral outcome which persists up to 4 weeks postinjury in rat. Naloxone treatment causes a modest and nonsignificant increase in mean arterial blood pressure (MAP). Naloxone (0.4 mg/kg) causes memory facilitation and antagonizes the amnestic effect of ACTH and epinephrine in rat. Naloxone treatment diminishes the strength of the initial tetanus in a dose-related manner in cats. Naloxone (5 or 10 mg/kg, i.v.) causes subsequent doses of morphine to produce less PTP depression but has no effect on maximal twitch depression.

N-Allyldihydro-14-hydroxynormorphinone | NIH 7890

Endocrinology/Hormones

Opioid Receptor

Opioid Receptor

Neurological Disease

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357-08-4

363.84

C19H21NO4·HCl

>98% (HPLC)

Water: 73 mg/mL (200.63 mM); DMSO: 73 mg/mL (200.63 mM)

C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl

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(-20℃)

With Ice Pack

≥ 2 years