Ziconotide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ziconotide is an atypical analgesic agent for the amelioration of severe and chronic pain. Derived from Conus magus, a cone snail, it is the synthetic form of an ω-conotoxin peptide.

Ziconotide is an atypical analgesic agent for the amelioration of severe and chronic pain. Derived from Conus magus, a cone snail, it is the synthetic form of an ω-conotoxin peptide.

Most native cells express a variety of different calcium channels and as a result, Ziconotide only partially reduces high-voltage-activated calcium currents in differentiated human neuroblastoma IMR32 cells, rat superior cervical ganglion neurons, and rat hippocampal neurons. Ziconotide also reduces calcium currents that result from expression of the α1B subunit in HEK cells, tsa-201 cells, and Xenopus laevis oocytes.Ziconotide delivers its antinociceptive efficacy by reducing the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, thereby inhibiting pain signal transmission.

Ziconotide (i.t.; 25-100 pmol/site; 5 μL; on the 4 th, 10 th, 15 th, 20 th, and 24 th days) reduces the levels of IL-1β and IL-23 in the CNS, as well as IL-17 production in the spleen, 25 days after MOG35-55-elicited EAE, in the mouse model of experimental autoimmune encephalomyelitis (EAE). Animal Model:Female C57BL/6mice (18-22 g, 6-8 weeks old) injected with myelin oligodendrocytes glycoprotein Dosage:25 pmol/site, 50 pmol/site, 100 pmol/site Administration:Intrathecal injection; on the 4 th, 10 th, 15 th, 20 th, and 24 th days Result:Significantly reduced the mechanical hypersensitivity in animals with EAE.

——

GPCR/G Protein

Calcium Channel

——

——

——

107452-89-1

2639.13

C102H172N36O32S7

>98% (HPLC)

——

——

Sequence:{Cys}{Lys}{Gly}{Lys}{Gly}{Ala}{Lys}{Cys}{Ser}{Arg}{Leu}{Met}{Tyr}{Asp}{Cys}{Cys}{Thr}{Gly}{Ser}{Cys}{Arg}{Ser}{Gly}{Lys}{Cys}-NH2(Disulfide bridge: Cys1-Cys16; Cys8-Cys20; Cys15-Cys25)

(-20℃)

With Ice Pack

≥ 2 years