Urolithin C

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

尿石素 C 是鞣花酸的肠道代谢产物。 Urolithin C 通过线粒体介导的途径诱导 PC12 细胞凋亡。

Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.(In Vitro):Urolithin C is a glucose-dependent activator of insulin secretion acting by facilitating L-type Ca2+ channel opening and Ca2+ influx into pancreatic β-cells.Urolithin C enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation as shown by higher phosphorylation levels in INS-1 β-cells. Urolithin C stimulates reactive oxygen species (ROS) formation.(In Vivo):In male Wistar rat, the half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V1/F) is 0.831 L/kg and the steady-state volume of distribution (Vss/F) is 55.6 L/kg after the intraperitoneal administration of Urolithin C (10 mg/kg).

Western Blot Analysis Cell Line:INS-1 cells Concentration:20 μM, 100 μM Incubation Time:1 hour Result:Enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation.

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Apoptosis

Apoptosis

Apoptosis

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165393-06-6

244.202

C13H8O5

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (204.75 mM)

Oc1ccc2c(c1)oc(=O)c1cc(O)c(O)cc21

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(-20℃)

With Ice Pack

≥ 2 years