Eleutheroside B1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

刺五加苷 B1 通过 POLR2A 和 N-糖基化介导其抗流感活性。 Eleutheroside B1 抑制多种趋化因子基因和流感核蛋白 (NP) 基因的 mRNA 表达，并表现出低细胞毒性。抗病毒和抗炎活性。

Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities.(In Vitro):eleutheroside B1 may affect N?glycan biosynthesis, the chemokine signaling pathway, cytokine?cytokine receptor interaction and, in particular, may target the POLR2A to inhibit the production of influenza virus genes.

Eeutheroside B1 (100?μg/ml; 24 hours) influences mRNA expression of host genes and virus genes in A549 cells. RT-PCR Cell Line:Virus-infected A549 cells Concentration:100?μg/ml Incubation Time:24 hours Result:The expression of host genes (MAN2A2, POLR2A) and virus genes (PA, PB1, PB2, HA) were decreased.

——

——

Microbiology/Virology

Influenza Virus

Influenza Virus

——

——

16845-16-2

384.337

C17H20O10

>98% (HPLC)

——

COc1cc2ccc(=O)oc2c(OC)c1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

——

(-20℃)

With Ice Pack

≥ 2 years