Ganoderic acid C1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

灵芝酸 C1 具有抗炎活性，具有治疗 TNF-α± 介导的哮喘和其他炎症性疾病的潜力。灵芝酸C1具有抗肿瘤促进活性。它是 HIV-1 蛋白酶的中等活性抑制剂。

Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic acid C1 has anti-tumor-promoting activity. It is moderately active inhibitors against HIV-1 protease.(In Vitro):Ganoderic acid C1 was isolated from G. lucidum. Stimulated RAW 264.7 macrophages were treated with Ganoderic acid C1. Human PBMCs and colonic biopsies were obtained from children with CD and cultured with or without Ganoderic acid C1. TNF-α± and other proinflammatory cytokine levels were measured in the culture supernatant. NF-κB signaling was investigated in PBMCs and colonic mucosa treated with Ganoderic acid C1 by In-Cell Western and Western blot analysis. GAC1 decreased TNF-α± production by macrophages and PBMCs from CD subjects. Ganoderic acid C1 significantly decreased TNF-α±, IFN-γ, and IL-17A production by inflamed colonic biopsies from CD subjects. These effects were due to the downregulation of the NF-κB signaling pathway.

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Apoptosis

IL Receptor

IL Receptor

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95311-97-0

514.659

C30H42O7

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (97.15 mM)

[H][C@@]12C[C@H](O)C3=C(C(=O)C[C@]4(C)[C@H](CC(=O)[C@@]34C)[C@H](C)CC(=O)C[C@@H](C)C(O)=O)[C@@]1(C)CCC(=O)C2(C)C

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(-20℃)

With Ice Pack

≥ 2 years