Ayanin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ayanin 具有血管舒张活性，也可能具有用于治疗过敏性哮喘的潜力。 Ayanin 抑制纯化嗜碱性粒细胞产生白细胞介素 IL-4 的 IC50 值为 2.2microM。 Ayanin 是一种非选择性磷酸二酯酶1-4 抑制剂，可用于呼吸系统疾病研究。

Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma. The IC50 value of Ayanin is 2.2microM for inhibiting interleukin IL-4 production from purified basophils. Ayanin is a non-selective phosphodiesterase1-4 inhibitor and can be used for respiratory disease researches.(In Vitro):Incubation of human leukemia cells with Ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by the overexpression of Bcl-x(L). Ayanin diacetate-induced cell death was found to be associated with: (i) loss of inner mitochondrial membrane potential, (ii) the release of cytochrome c, (iii) the activation of multiple caspases, (iv) cleavage of poly(ADP-ribose) polymerase and (v) the up-regulation of death receptors for TRAIL, DR4 and DR5. Moreover, the combined treatment with Ayanin diacetate and TRAIL amplified cell death, compared to single treatments.

Ayanin inhibits interleukin (IL)-4 production from purified basophils with an IC50 value of 2.2 μM.

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Apoptosis

IL Receptor

IL Receptor

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572-32-7

344.319

C18H16O7

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (726.07 mM)

COc1cc(O)c2c(c1)oc(-c1ccc(OC)c(O)c1)c(OC)c2=O

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(-20℃)

With Ice Pack

≥ 2 years